| Abstract |
13379185440邮箱：th39977@163.com邮编： 727000针刺联合抗抑郁药对脑梗死后抑郁症患者日常生活能力及认知功能的影响郭莉娟 高韩宁 张秋凤 邓淑琴 李君 铜川矿务局中心医院神经内科理疗室 陕西铜川 727000摘要 目的 分析针刺联合抗抑郁药对脑梗死后抑郁症患者日常生活能力及认知功能的影响。方法：本次研究对象为2014年9月~2016年7月在铜川矿务局中心医院神经内科理疗室进行治疗的60例脑梗死后抑郁症患者，其中单一抗抑郁药治疗的30例患者列入对照组，30例采用针刺联合抗抑郁药治疗的患者列为观察组，分别于治疗前、治疗15d及疗程结束后对患者抑郁状态〔汉密顿抑郁量表（HAMD）〕、日常生活能力〔Barthel指数（BI）〕、认知功能〔蒙特利尔认知评估量表（MoCA）〕进行评价，以HAMD改善程度判定疗效，并统计不良反应发生率。结果 ①观察组总有效率为93.33%，高于对照组的73.33%，对比差异有统计学意义（P＜0.05）；②治疗前两组患者的HAMD评分、BI指数、MoCA评分对比无差异，治疗后HAMD评分下降、BI指数及MoCA评分上升，且观察组各时间节点的HAMD评分低于对照组，BI指数及MoCA评分高于对照组，对比差异有统计学意义（P＜0.05）；③ 观察组不良反应发生率为10.00%，低于对照组的30.00%，对比差异有统计学意义（P＜0.05）。 结论 针刺联合抗抑郁药对改善脑梗死后抑郁症患者日常生活能力及认知功能具重要意义，并能减少抗抑郁药物所致的不良反应。关键词 针刺；抗抑郁药；脑梗死后抑郁症；日常生活质量；认知功能Effects of Acupuncture Combined with Antidepressants on Daily Living Ability and Cognitive Function in Patients with Depression after Cerebral InfarctionGuoLiJuan, gao hanning,zhang qiufeng,deng shuqin,lijunDepartment Of Neurology and Physiotherapy room Central Hospital of Tong chain Mining Bureau shanxi tongchuan 727000Abstract Objective: To analyze the effects of acupuncture combined with antidepressants on daily living ability and cognitive function in patients with depression after cerebral infarction. Methods The study was conducted in 60 patients with depression after cerebral infraction treated in the physiotherapy room of department of neurology of the Central Hospital of Tongchuan Mining Bureau from September 2014 to July 2016. Among them, 30 patients with single antidepressants therapy were included in the control group and other 30 patients treated with acupuncture combined with antidepressants were enrolled in the observation group. The depression status [the Hamilton Depression Scale(HAMD)], daily living ability [Barthel index (BI)], cognitive function [the Montreal Cognitive Assessment Scale (MoCA)] were measured before treatment, at 15 days of treatment and after treatment, and the curative effect was evaluated by the improvement degree of HAMD, and the incidence rate of adverse reactions was statistically evaluated. Results ①The total effective rate was 93.33% in the observation group, which was higher than that of the control group with 73.33%, and the difference was statistically significant (P<0.05). ② There were no differences in HAMD score, BI index and MoCA score between the two groups before treatment. And after treatment, the HAMD score was decreased, and the BI index and MoCA score were increased, and the HAMD score of the observation group was lower than that in the control group while the BI index and MoCA score were higher than those in the control group at each time point (P<0.05). ③ The incidence rate of adverse was 10.00% in the observation group, which was lower than that of the control group with 30.00%, and the difference was statistically significant (P<0.05). Conclusions Acupuncture combined with antidepressants can have significance in improving the daily life ability and cognitive function, and can reduce the adverse reactions caused by antidepressants in the treatment of patients with depression after cerebral infarction.
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