Journal of International Psychiatry

Objective:To explore the relationships between prenatal risk factors and tic disorders (TDs), and provide a scientific basis for the prevention of TDsMethod: In the 1:1 matched case control study，150 children with TDs from west china second hospital and 150 healthy individuals were enrolled，and were investigated used a questionnaire to collect information of prenatal risk factors. Univariate and multivariate logistic regression were used to assess the effects of each related factor on TDs risk．Result: In the case group, 150 newly diagnosed patients with TDs were included, 110 were male, and the age was 9.18±2.60. In the control group, 109 cases were men, and the age was 9.09±2.52.Univariate logistic regression showed that pregnant age, pregnancy reaction, birth complications, perinatal asphyxia, passive smoking during pregnancy, the mental stimulation and gestational age were the risk factors for TDs (P<0.05). Multivariate logistic regression showed that the risk factors of TDs were pregnancy age, delivery complications, passive smoking, pregnancy and mental stimulation.Conclusion: Pregnancy age, delivery complications, passive smoking, pregnancy and mental stimulation may be associated with TDs. Health education for the disease should be strengthened and avoiding prenatal risk factors should beadvocated to prevent TDs．

children, tic disorder, risk factors, matched case-control study, logistic regression