Journal of International Psychiatry

Abstract：Objective: To investigate the effects of thyroid hormone on the onset of depression. METHODS: Sixty patients with depression were enrolled from our hospital from December 2017 to December 2018. At the same time, 60 healthy subjects were selected. The patients with depression were treated as observation group, and the healthy ones were used as control group. The thyroid stimulating hormones of the two groups were tested. (TSH) levels, tetraiodothyronine (T4), and triiodothyronine (T3) were compared and analyzed. Personal correlation analysis was performed on each factor of HAMD assessment. RESULTS: There was no significant difference in TSH between the observation group and the control group (P>0.05). The T3 and T4 of the observation group were significantly lower than those of the control group (P<0.05). The T3 and T4 of different genders in the observation group were significantly lower than those in the control group (P<0.05). The T3 of different ages in the observation group was lower than that of the control group (P<0.05). The T3 of the patients in the observation group was significantly lower than that of the control group (P<0.05). The patients with the disease course of 12-24 months and 24-60 months were significantly lower than the control group (P<0.05). The patients TSH and HAMD total scores and duration of disease were positively correlated. The patients course of disease was negatively correlated with the blocker and positively correlated with T3. Conclusion: Depressive patients have abnormal thyroid function. Thyroid hormone may participate in the formation of depression, which is one of the causes of depression.Key words：Thyroid hormone; depression; triiodothyronine