Journal of International Psychiatry

Objective To investigate the correlation between serum interleukin-33 (IL-33) and incidence of depression in postoperative elderly patients with cervical cancer. Methods A total of 315 patients with cervical cancer after operation from two hospitals were divided into depression group and non-depression group according to the incidence of depression. The differences of serum IL-33 levels between the two groups was compared. Pearson correlation analysis was used to analyze the correlation between serum IL-33 levels and the severity of depression. Logistic regression was also used to analyze whether IL-33 was a risk factor for depression in postoperative patients with cervical cancer. Receiver Operating Characteristic (ROC) curve was used to analyze the clinical value of IL-33 in predicting depression in postoperative patients with cervical cancer. Results The serum IL-33 levels in depression group (345.12±61.34) ug/L was significantly higher than that non-depression group (216.19±35.56) ug/L, and the difference was statistically significant (t=22.123, P<0.000). The Pearson results showed that IL-33 was positively correlated with the severity of depression with correlation coefficient was 0.652. IL-33 was an independent risk factor for depression in postoperative cervical cancer patients (OR=3.712). The clinical value of IL-33 in predicting depression in postoperative patients with cervical cancer was significantly AUC=0.837 (95% CI: 0.778-0.896). When the cut-off value was 369.47ug/L, the sensitivity and specificity were 77.9% and 74.5%, respectively. Conclusions: Serum IL-33 is significantly associated with depression in postoperative patients with cervical cancer. IL-33 may be involved in the pathogenesis of depression.

Interleukin-33；Postoperative of cervical cancer；Depression；ROC curve