| Abstract |
Objective: To investigate the results of cognitive impairment and related influencing factors in patients with multiple sclerosis. METHODS: Fifty patients with multiple sclerosis were enrolled in our hospital from February 2017 to February 2019. They were enrolled in the observation group and 50 healthy subjects were enrolled in the same period. MRI) and the Montreal Cognitive Assessment Scale (MoCA) test results, and the Extended Disorder Status Scale (EDSS) was used to assess the degree of neurological deficits in the observation group, and to analyze the characteristics of cognitive impairment and related influencing factors. RESULTS: In the observation group, the language, delayed memory, naming, visual space and execution, total score and control group were statistically significant (P<0.05); while orientation, attention, abstraction, calculation and comparison with the control group There was no statistical difference (P>0.05). According to the MoCA scale test, the observation group showed 33 cases lower than the normal standard, accounting for 66%. There were differences in the classification and duration of the patients with MoCA abnormality (P<0.05), but there was no significant difference between the MRI lesion grade, EDSS score and education years (P>0.05). Using Pearson correlation analysis, MoCA was associated with patients with different types and duration of disease (P<0.05), but had no significant correlation with MRI lesion grade, EDSS score, and years of education (P>0.05). There was a negative correlation between EDSS and executive function (P<0.05). Conclusion: Patients with clinical multiple sclerosis complicated with cognitive impairment have the most serious damage to visual space and executive function, language function, delayed memory function and naming function, but the orientation ability, attention ability, abstract ability and computing ability are not obvious. The more severe the degree of physical dysfunction, the lower the executive function and visual spatial scores; the degree of cognitive impairment is closely related to the classification and duration of the disease.
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