| Abstract |
objective To explore the relationship between plasma kynurenine and postoperative depression in women with renal cancer, aiming to improve the prognosis of patients with renal cancer after surgery. Method 94 patients with renal cell carcinoma who were treated in our hospital from August 2017 to February 2019 were selected as subjects. Patients were divided into two groups according to the Beck Depression Scale (BDI) score. The BDI score of the observation group was ≥14 points, a total of 27 cases, and the control group had a BDI score of <14 points, a total of 67 cases. The levels of inflammatory factors (TNF-α, IL-6), tryptophan, and kynurenine were compared between the two groups, and multivariate logisitic regression was used to analyze the risk factors for postoperative depression in women with renal cancer. Result The TNF-α level in the observation group was 10.23±1.19 ng/mL, the IL-6 level was 9.21±1.86 ng/L, the TNF-α level in the control group was 2.08±0.17 ng/mL, and the IL-6 level was 2.27±1.85 ng/ L(P<0.05). The level of tryptophan in the observation group was 17.85±4.21umol/L, the level of kynurenine was 5.73±2.04ug/L, the level of tryptophan in the control group was 24.74±3.69umol/L, and the level of kynurenine was 4.11±1.67. Ug/L (P<0.05). Multivariate Logisitic regression analysis showed that high TNF-α levels, high IL-6 levels, low tryptophan levels, and high kynurenine levels were risk factors for postoperative depression in women with kidney cancer. Conclusion Postoperative depression in women with renal cancer is closely related to inflammatory status, tryptophan and plasma kynurenine, increased inflammatory status, decreased tryptophan levels, and elevated kynurenine levels suggesting a risk of depression.
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