双相情感障碍共病代谢综合征患者血清同型半胱氨酸水平及认知功能的影响因素
The level of serum homocysteine and factors affecting cognitive function in bipolar disorders complicated with metabolic syndrome
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| DOI |
| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2020, 47(2) |
| 作者 |
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| 作者单位 |
山东省临沂市精神卫生中心 ;
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| 摘要 |
了解双相情感障碍共病代谢综合征（MS）患者的血清同型半胱氨酸（Hcy）水平及认知功能水平，探讨双相障碍患者认知功能的影响因素。方法 对2018年1月至 2019 年6月在临沂市精神卫生中心住院的双相情感障碍患者做调查，共纳入120例患者，根据有无MS分为研究组（伴MS）和对照组（不伴有MS），采用蒙特利尔认知评估量表（MOCA）评估并比较两组的认知功能及与MS、Hcy等因素的相关性。结果 120例双相情感障碍患者中共病代谢综合征者有60例，占50%，研究组的Hcy水平显著高于对照组 [ 结果为（14.30士5.07）VS（11.96士3.34），P<0.05]，研究组的MOCA总分显著低于对照组 [（16.85士6.57）VS（20.65士3.99），P<0.05]。以MOCA总分为因变量，分别以一般资料、MS、Hcy等为自变量，进行pearson相关分析，结果MOCA总分与MS、Hcy、双相抑郁/躁狂量表评分、受教育年限、年龄、病程、血糖、收缩压、总胆固醇、低密度胆固醇、高密度胆固醇均相关，相关系数分别为0.333、-0.602、-0.672、0.416、-0.600、-0.319、-0.182、-0.354、-0.275、-0.187、-0.199（p<0.05），多因素线性回归分析显示，MOCA总分与双相抑郁/躁狂量表评分、HCY水平、年龄、病程、有代谢综合征均呈负关联[（β分别为-0.444、-0.563、-0.087、-0.083、2.173），P<0.05]，与受教育年限呈正关联（β=0.210，P<0.05）。结论 共病代谢综合征的双相障碍患者具有更高水平的同型半胱氨酸及更差的认知功能，其认知功能下降的影响因素可能与病情严重、高同型半胱氨酸水平、共病代谢综合征、病程长、高龄有关。
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| Abstract |
Objective Investigating the serum homocysteine (Hcy) and cognitive function in bipolar disorders complicated with metabolic syndrome, To explore the influencing factors of cognitive function in bipolar disorders. Methods Investigating patients with bipolar disorder in the mental health center of linyi from January 2018 to June 2019 , A total of 212 patients with bipolar disorder were recruited and divided into study group ( with MS) and control group ( without MS)．The cognitive function of the two groups and the correlation with MS, Hcy and other factors were evaluated and compared using the MOCA. Results The patients with bipolar disorders had a MS prevalence of 50%．The level of Hcy in the study group was significantly higher than that in the control group [respectively（14.30士5.07）VS（11.96士3.34），P<0.05]，the totol score of MOCA in the study group was significantly lower than that of the control group [（16.85士6.57）VS（20.65士3.99），P<0.05]. Multi-factor linear regression analysis showed that the totol score of MOCA was negatively associated with Bipolar depression/mania scale score, HCY level, age, course of disease、MS[（respectively β -0.444、-0.563、-0.087、-0.083、2.173），P<0.05]，and positively associated with education years（β=0.210，P<0.05）. Conclusions Patients with bipolar disorder complicated with metabolic syndrome have higher levels of Hcy and poorer cognitive function, the influencing factors of cognitive impairment may be related to severe disease,high Hcy level, complicated with MS, long course of disease and advanced age.
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| 关键词 |
双相情感障碍；代谢综合征；同型半胱氨酸；认知功能
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| KeyWord |
Bipolar disorder;Metabolic syndrome ;Homocysteine;Cognitive function
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| 基金项目 |
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| 页码 |
285-288 |
常桂花*.
双相情感障碍共病代谢综合征患者血清同型半胱氨酸水平及认知功能的影响因素 [J].
国际精神病学杂志.
2020; 47; (2).
285 - 288.