| Abstract |
Objective: To explore the effect of anxiety on blood pressure variability (BPV), endothelin-1 (ET-1) and nitric oxide (NO) in pregnant women with hypertension. Methods: 144 pregnant women with hypertension who were treated in our hospital from April 2018 to August 2019 were selected as the study objects. According to the SAS score, the patients were divided into control group, observation group 1 and observation group 2. 58 cases of PIH were in the control group, 49 cases of PIH with mild anxiety were in the observation group 1, 37 cases of PIH with moderate or severe anxiety were in the observation group 2. BPV indexes such as 24-hour systolic standard deviation, 24-hour diastolic standard deviation, daytime systolic standard deviation, daytime diastolic standard deviation, nighttime systolic standard deviation and nighttime diastolic standard deviation were compared among the three groups; ET-1 and NO levels were compared between the two groups; the relationship between BPV indexes and ET-1 and NO was studied by logistic multi factor regression analysis.Results: A comparison of BPV indicators found that the difference smaller than the standard difference of 24h systolic pressure, the standard difference of systolic pressure between the three groups, the standard difference of night systolic pressure and the standard difference of night systolic pressure was statistically significant, and the index above 2 of the observation group was at a higher level, P<0.05. Compared with NO and ET-1, ET-1 level in control group was 58.34 ± 16.78ng/l, NO level was 81.22 ± 6.84 μ mol / L, ET-1 level in observation group was 76.98 ± 20.51ng/l, NO level was 70.02 ± 9.45 μ mol / L, ET-1 level in observation group was 95.30 ± 18.77ng/l, NO level was 64.32 ± 5.19 μ mol / L, with statistical significance P < 0.05. Logistic regression analysis showed that 24-hour systolic blood pressure standard deviation, night systolic blood pressure standard deviation and night diastolic blood pressure standard deviation were the related factors affecting the level of ET-1 and no, the difference was statistically significant (P < 0.05). Conclusion: anxiety can affect the blood pressure variability of pregnant women with hypertension, and further cause the changes of endothelin-1 and nitric oxide content. Early recognition of anxiety in pregnant women with hypertension is of positive significance to reduce the impairment of endothelial function and improve the condition of hypertension.
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