| Abstract |
【Abstract】 Obejective To explore the effect of olanzapine combined with risperidone on metabolism and curative effect of schizophrenia. Methods Patients with schizophrenia were randomly divided into three groups: group A, group B and group C. The three groups were treated by olanzapine, risperidone, and olanzapine combined with risperidone respectively. The fasting blood sugar(FBG),blood uric acid(BUA), triglyceride(TG), total cholesterol(TC), low density lipoprotein (LDL-C), high density lipoprotein (HDL-C),Body Mass Index(BMI) and negative and positive scale scores (PANSS) were performed before the treatment and at the 3rd month after treatment. Rusults 180 patients completed the study. 61 patients in group A, 72 patients in group B and 47 patients in group C. There were a rise in FBG, BUA, TC, TG, LDL-C, BMI and PANSS scores decreased after three months of treatment（group A, t=-4.114,t=-4.735,t=-12.863,t=-7.308,t=-11.390,t=-3.915,t=6.536; group B, t=-3.675,t=-1.068,t=-11.374,t=-7.640,t=-7.188,t=-2.349,t=6.145; group C, t=-3.539,t=-5.186,t=-14.225,t=-6.149,t=-13.524,t=-4.968,t=7.218) The difference was statistically significant (P < 0.01); There was no significant difference in FBG, BUA,TC,TG,HDL-C,LDL-C,BMIand PANSS score among the three groups before treatment (P > 0.05). There was no significant difference in FBG, TG, HDL-C and PANSS between the three groups at the 3rd month after treatment (P > 0.05). There were significant differences in BUA (F = 12.493, P = 0.000), TC (F = 7.706, P = 0.001),LDL-C (F = 9.650, P = 0.000) and BMI (F = 3.363, P = 0.037) among the three groups. The BUA,TC, LDL-C and BMI of group A and group C were higher than those of group B. Conclusions Olanzapine has more effect on metabolism than risperidone. Compared with olanzapine alone, Olanzapine combined with risperidone did not increase the risk of metabolic syndrome, but also did not increase the efficacy. Therefore, the combination of antipsychotics should be careful in clinical practice.
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