Journal of International Psychiatry

【 Abstract 】Objective To explore the therapeutic effect of olacetam in patients with vascular dementia (VD) after acute cerebral infarction and its effects on brain neuron damage factor, serum IGF-1 and cognitive function. Methods 107 patients with VD after acute cerebral infarction in our department were selected and divided into groups according to random number table. Fifty-three patients in the control group were given conventional treatment as recommended by the guidelines, and 54 patients in the observation group were additionally treated with olacetam. The clinical efficacy, cognitive function, brain neuron injury factor and vascular endothelial injury indexes of the two groups were compared. RESULTS: After treatment, MMSE score, IGF-1, VEGF, VWF, EPC level and total effective rate in observation group were higher than those in control group, while Tau protein, S100β protein, HIF-1α, NSE and ET were lower than those in control group (P<0.05).CONCLUSIONS: Orazetam combined guidelines recommend routine treatment of patients with vascular dementia after acute cerebral infarction, which can effectively reduce vascular endothelial function and brain neuroelement damage, promote the recovery of cognitive function, and improve clinical efficacy

【 Key words 】 Orazetam; Acute cerebral infarction; Vascular dementia