| Abstract |
[Abstract] Objective To investigate the risk factors of cognitive dysfunction in patients with sepsis and provide a theoretical basis for the prevention of cognitive dysfunction. Methods A total of 84 surviving patients with sepsis from January 2019 to January 2021 were selected to investigate the occurrence of cognitive dysfunction within 1 week after the vital signs were stabilized. Compare the age, gender, comorbidities and other medical records of patients with cognitive dysfunction and normal patients. Single factor and binary logistic regression analysis were used to investigate the risk factors of cognitive dysfunction in patients with sepsis. Results Cognitive dysfunction occurred in 104 patients with sepsis in 40 cases. Cognitive dysfunction group and normal group age, duration of delirium, severity of sepsis, combined hypoxemia, history of benzodiazepine use, hyperglycemia, years of education, acute physiological function and chronic health score System Ⅱ (APACHE Ⅱ) score, sequential organ failure score (SOFA), and mechanical ventilation time were significantly different (P<0.05). There was no significant difference between the two groups in gender, length of ICU hospitalization, and years of education (P>0.05). Binary logistic regression analysis showed that age> 60 years, duration of delirium, septic shock, combined with hypoxemia, history of benzodiazepine use, and combined with hyperglycemia were risk factors for cognitive dysfunction in patients with sepsis. Conclusion Surviving patients with sepsis have a higher incidence of cognitive dysfunction. Risk factors include age, delirium, septic shock, etc., and targeted intervention measures should be taken according to the risk factors to reduce the incidence of cognitive dysfunction.
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