运动性引导想象训练结合度洛西汀对脑梗死后伴发抑郁焦虑患者神经认知功能、血清NGF及BDNF水平的影响
Effects of exercise guided imagination training combined with duloxetine on neurocognitive function, serum NGF and BDNF levels in patients with depression and anxiety after cerebral infarction
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| DOI |
| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2022, 49(4) |
| 作者 |
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| 作者单位 |
开封市中心医院神经电生理室 ;
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| 摘要 |
【摘要】 分析给予脑梗死患者应用度洛西汀联合运动性引导想象训练治疗后效果。方法 采用掷币法将我院115例脑梗死后伴发抑郁焦虑患者分组，药物组57例予度洛西汀，58例联合组增加运动性引导想象训练，对比神经功能、认知功能、焦虑、抑郁情绪、神经递质水平。结果 治疗4周后，联合组脑源性神经营养因子(BDNF)、5-羟色胺(5-HT)、血清神经生长因子(NGF)、去甲肾上腺素(NE)水平高于药物组（P<0.05）；汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)、美国国立卫生研究院卒中量表(NIHSS)评分低于药物组，简易智力状态检查表(MMSE)评分高于药物组（P<0.05）。结论 在度洛西汀基础上增加运动性引导想象训练，能够更为有效的转变脑梗死后伴发抑郁焦虑患者负面情绪，改善认知功能及神经功能。
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| Abstract |
【Abstract】 Objective To analyze the effects of duloxetine combined with exercise guided imaging training for patients with cerebral infarction. Methods 115 patients with depression and anxiety after cerebral infarction in our hospital were divided into groups by coin tossing. 57 patients in the drug group were given duloxetine, and 58 patients in the combined group were given motor-guided imagination training. The neurological function, cognitive function, and anxiety were compared. Depression, neurotransmitter levels. Results After 4 weeks of treatment, the brain-derived neurotrophic factor (BDNF), 5-hydroxytryptamine (5-HT), serum nerve growth factor (NGF), and norepinephrine (NE) levels in the combined group were higher than those in the drug group (P< 0.05); Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), National Institutes of Health Stroke Scale (NIHSS) scores are lower than the drug group, and the Mini Mental State Checklist (MMSE) score is higher than the drug group ( P<0.05). Conclusion Adding exercise guided imagination training on the basis of duloxetine can more effectively change the negative emotions of patients with depression and anxiety after cerebral infarction, and improve cognitive and neurological functions.
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| 关键词 |
【关键词】运动性引导想象训练；度洛西汀；脑梗死；抑郁焦虑
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| KeyWord |
[Keywords] exercise guided imagination training; duloxetine; cerebral infarction; depression and anxiety
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| 基金项目 |
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| 页码 |
672-674 |
张宁*.
运动性引导想象训练结合度洛西汀对脑梗死后伴发抑郁焦虑患者神经认知功能、血清NGF及BDNF水平的影响 [J].
国际精神病学杂志.
2022; 49; (4).
672 - 674.