Journal of International Psychiatry

[Abstract] Objective: To explore the correlation between post-stroke depression and serum homocysteine (Hcy) level and cystatin C (CysC) level in the elderly. Methods: Selection in our hospital on December 1, 2018 to January 1, 2020 in the hospital and diagnosed 121 cases of elderly patients with acute cerebral ischemic stroke, according to the Hamilton depression rating scale (HAMD) to evaluate patients with depressive symptoms, grouped according to whether depression, 66 cases of patients with poststroke depression as the observation group, 55 patients with poststroke depression as the control group, General information, such as gender and age, and serum Hcy level and CysC level of patients in the two groups were analyzed, and the correlation between post-stroke depression and serum Hcy level and CysC level was analyzed by 2-yuan Logistic regression. Results: There was no significant difference in age, gender, diabetes history, hypertension history and other general information between 2 groups (P>0.05). The serum Hcy and CysC levels in the observation group were significantly higher than those in the control group (P<0.05). By 2-yuan logistic regression analysis, serum Hcy and CysC levels were positively correlated with poststroke depression (P<0.05). Conclusions: Serum Hcy and CysC levels in stroke patients increase the risk of poststroke depression. Clinical attention should be paid to serum Hcy and CysC levels in stroke patients to reduce the occurrence of poststroke depression.

【 Key words 】 Poststroke depression; Homocysteine; Cystatin C; The correlation