自然杀伤细胞（NK）在乙肝病毒感染及相关肝脏疾病中的作用和机制研究进展-细胞与分子生物学研究-CSCIED科技核心评价数据库-手机版

自然杀伤细胞（NK）在乙肝病毒感染及相关肝脏疾病中的作用和机制研究进展

The role and mechanism of natural killer cells (NK) in hepatitis B virus infection and related liver diseases

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DOI	10.12208/j.ijcmbr.20220001
刊名	细胞与分子生物学研究 Journal of Cell and Molecular Biology Research
年，卷(期)	2022, 2(1)
作者	单关月,王帅,刘菲,李海军,
作者单位	吉林大学第一医院转化医学研究院吉林长春 ; 吉林大学第一医院产科吉林长春 ;
摘要	乙型肝炎病毒（HBV）感染是全球严重的公共卫生问题之一，HBV感染会引起肝脏的一系列并发疾病，包括肝炎、肝纤维化、肝硬化和肝癌。自然杀伤细胞（NK）是机体内重要的免疫细胞，尤其在肝脏免疫中发挥重要作用。NK细胞表面表达多种协同共刺激性分子和共抑制性分子，通过这些分子的表达调控NK细胞活性。HBV慢性持续性感染会上调NK细胞表面协同共抑制性分子的表达而使其杀伤和分泌细胞因子的能力受损，明显削弱NK细胞的功能，加重肝脏免疫耐受，最终导致肝纤维化或肝癌的发生。本文总结了HBV感染过程中NK细胞的功能变化，以及NK细胞与肝内其他细胞间的相互作用，旨在为以NK细胞为中心的HBV相关疾病的治疗和免疫学干预提供依据。
Abstract	Hepatitis B virus (HBV) infection is one of the major public health problems in the world. HBV infection cause a series of liver diseases, including hepatitis, liver fibrosis, liver cirrhosis and liver cancer. Natural killer cells (NK) are important immune cell subsets in the liver. A variety of co-stimulatory and co-inhibitory molecules are expressed on the surface of NK cells. Chronic HBV infection increase the expression of synergistic co-inhibitory molecules on the surface of NK cells, impair their killing ability and cytokine secretion. NK cell inhibition contribute further aggravate liver immune tolerance, and finally lead to liver fibrosis or liver cancer. This review summarizes the functional changes of NK cells in the process of chronic HBV infection and the interaction between NK cells and other immune cells in the liver, in order to provide basis for the treatment of HBV related diseases centered on NK cells.
关键词	自然杀伤细胞；乙型肝炎病毒；肝纤维化；肝癌
KeyWord	Hepatitis B virus; Vertical transmission; Pregnancy; Antiviral drugs
基金项目
页码	1-7

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引用本文

单关月,王帅,刘菲*,李海军*. 自然杀伤细胞（NK）在乙肝病毒感染及相关肝脏疾病中的作用和机制研究进展 [J]. 细胞与分子生物学研究. 2022; 2; (1). 1 - 7.

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