依托咪酯与丙泊酚混合液在小儿全身麻醉诱导中的临床研究-国际医药研究前沿-CSCIED科技核心评价数据库-手机版

依托咪酯与丙泊酚混合液在小儿全身麻醉诱导中的临床研究

Clinical study of etomidate and propofol mixture in pediatric induction of general anesthesia

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DOI	10.12208/j.imrf.20220106
刊名	国际医药研究前沿 International Medical Research Frontier
年，卷(期)	2022, 6(3)
作者	封少梅*,
作者单位	山东省莱西市市立医院山东青岛 ;
摘要	探究小儿全身麻醉诱导中应用依托咪酯与丙泊酚混合液的临床效果。方法回顾本院2021.6-2022.6之间全身麻醉诱导干预患儿90例进行研究，其中使用依托咪酯与丙泊酚混合液的视为联合组（EP组），单独使用依托咪酯、丙泊酚视为依托咪酯组（E组）、丙泊酚组（P组），以双盲法各入组30例，对比三组四点口述分级评分法VRS-4、Blitt分级、Ricker镇静-躁动评分(SAS)的相关数据。结果三组疼痛从轻到重的程度依次为E组>EP组>P组，P<0.05。三组肌颤从轻到重的程度依次为P组>EP组>E组。三组镇静-躁动从优到差的顺序依次是EP组>E组>P组。（P<0.05）。结论全身麻醉诱导中，依托咪酯与丙泊酚混合液可稳定患儿的血压、减少患儿体征的波动，肌颤躁动、注射痛的比例少，无论是单独应用依托咪酯还是丙泊酚，其效果都远不如依托咪酯与丙泊酚混合液产生的麻醉安全效果，混合液诱导形式具有推广意义。
Abstract	Objective To explore the clinical effect of etomidate and propofol mixture in the induction of general anesthesia in children. Methods Review 90 children with general anesthesia induction intervention between 2021.6-2022.6, using etomidide and propofol mixture as combination group (group EP), etomidate and propofol group (group E) and propofol (group P), study 30 patients in double-blind method and compare the data of VRS-4, Blitt grade, Ricker sedation-agitation score (SAS). Results Three mild to severe pain groups were group E>EP group>P group, and P<0.05. The degree of muscle fibrillation from light to heavy in the three groups was group P>EP>E. The order of sedation-agitation was EP>E>P (P<0.05). Conclusion general anesthesia induction, etomidate and propofol mixture can stabilize children with blood pressure, reduce the fluctuation of signs, muscle fibrillation agitation, injection pain, whether used alone etomimidate or propofol, its effect is far less than etomimidate and propofol mixture anesthesia safety effect, mixture induction form has promotion significance.
关键词	依托咪酯；丙泊酚；混合液；小儿全身麻醉诱导
KeyWord	Etomidate; propofol; Mixture; Pediatric general anesthesia induction
基金项目
页码	56-59

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引用本文

封少梅*. 依托咪酯与丙泊酚混合液在小儿全身麻醉诱导中的临床研究 [J]. 国际医药研究前沿. 2022; 6; (3). 56 - 59.

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