International Journal of Materials Science

Nanoparticles were prepared using γ-polyglutamic acid(PGA), curcumin, and chitosan(CS) as matrix, polyvinylpyrrolidone(PVP) and sodium tripolyphosphate(STPP) as stabilizers and cross-linking agents. The optimal formula was determined by comparing the encapsulation rate, structural characterization and infrared spec- troscopy of curcumin in nanoparticles with different concentration ratio formulations; the in vitro release of nano- particles containing curcumin in two media were investigated by dynamic dialysis. The optimum formula for the production of curcumin nanoparticles were obtained as follows: curcumin concentration was 0.26mg/mL, PGA concentration was 0.2%, STPP concentration was 0.2%, PVP concentration was 0.1% and CS concentration was 0.02%(in 100mL aqueous solution). The average particle size of the nanoparticles was 526.3nm and the dispersion coefficient was 0.288. The prepared nanoparticles had a good slow release effect on curcumin.

Curcumin; γ-polyglutamic acid; Nanoparticles; Preparation; Slow release