FoxP3、TGF-β和IL-10在子宫内膜癌中表达的研究进展-国际肿瘤研究杂志-CSCIED科技核心评价数据库-手机版

FoxP3、TGF-β和IL-10在子宫内膜癌中表达的研究进展

Research progress on the expression of FoxP3, TGF-β and IL-10 in endometrial carcinoma

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DOI	10.12208/j.ijcan.20220003
刊名	国际肿瘤研究杂志 International Journal of Cancer Research
年，卷(期)	2022, 3(1)
作者	武艳芳,索静*,
作者单位	内蒙古医科大学附属医院妇产科内蒙古呼和浩特 ;
摘要	肿瘤免疫微环境在肿瘤的发生、发展和转移中起着重要的作用。在子宫内膜癌中，免疫系统的监视、杀伤能力明显降低，免疫微环境中多种组分的构成和功能的改变均能促进疾病的发生及演进。其中，FoxP3、TGF-β和IL-10免疫分子的上调是多种肿瘤细胞免疫逃逸的重要机制，在子宫内膜癌中对其进行研究有助于探索子宫内膜癌的发病机制和发展新的抗癌疗法。因此，本文就近年来子宫内膜癌免疫微环境中免疫分子FoxP3、TGF-β和IL-10表达的研究进展作以下综述。
Abstract	Tumor immune microenvironment plays an important role in the occurrence, development and metastasis of tumors. In endometrial cancer, the surveillance and killing ability of the immune system are significantly reduced. The changes in the composition and function of various components in the immune microenvironment can promote the occurrence and evolution of the disease. Among them, the upregulation of FoxP3,TGF-β and IL-10 immune molecules is an important mechanism of immune escape of various tumor cells. Studying them in endometrial cancer will help to explore the pathogenesis of endometrial cancer and develop new anticancer therapies. Therefore, this article reviews the research progress on the expression of immune molecules FoxP3,TGF-β and IL-10 in the immune microenvironment of endometrial cancer in recent years.
关键词	子宫内膜癌；肿瘤免疫逃逸；FoxP3；TGF-β；IL-10
KeyWord	Endometrial carcinoma; Tumor immune escape; FoxP3; TGF-β; IL-10
基金项目
页码	11-15

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武艳芳,索静*. FoxP3、TGF-β和IL-10在子宫内膜癌中表达的研究进展 [J]. 国际肿瘤研究杂志. 2022; 3; (1). 11 - 15.

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