MiRNA在宫颈癌放射敏感性中作用机制的研究进展

Research progress on the mechanism of MiRNA in radiosensitivity of cervical cancer

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DOI 10.12208/j.imrf.20220095
刊名
International Medical Research Frontier
年,卷(期) 2022, 6(3)
作者
作者单位

延安大学附属医院妇科 陕西延安 ;
西安市第三医院病理科 陕西西安 ;

摘要
宫颈癌是我国常见的妇科恶性肿瘤之一,中晚期宫颈癌主要的治疗方式为放射治疗,提高放射治疗敏感性是改善宫颈癌患者预后的关键。近年来研究发现,miRNA在宫颈癌放射敏感性中具有重要的调控作用。本文对miRNA调节宫颈癌放疗敏感性的作用及机制做一综述,强调了miRNA在未来肿瘤诊断和治疗中的临床前景,并进一步阐述了探索新机制和发现新靶点对提高放疗疗效的意义。
Abstract
Cervical cancer is one of the common gynecological malignant tumors in China. The main treat- ment for intermediate and advanced cervical cancer is radiotherapy. Improving radiotherapy sensitivity is the key to improve the prognosis of patients with cervical cancer. In recent years, miRNA has been found to play an important role in the regulation of radiosensitivity in cervical cancer. In this paper, we reviewed the role and mechanism of miRNA in regulating radiotherapy sensitivity of cervical cancer, emphasized the clinical prospect of miRNA in tumor diagnosis and treatment in the future, and further expounded the significance of exploring new mechanisms and discovering new targets for improving radiotherapy efficacy.
关键词
宫颈癌;MiRNA;放射敏感性;分子标志物
KeyWord
Cervical cancer; Micrornas; Radiosensitivity; Molecular marker
基金项目
页码 14-17
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王佳敏,左伟晨,杨小艳,雷侠*. MiRNA在宫颈癌放射敏感性中作用机制的研究进展 [J]. 国际医药研究前沿. 2022; 6; (3). 14 - 17.

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