International Medical Research Frontier

Objective To study the protective effect of silybin on Alzheimers disease animal model. Methods the purchased 90 experimental mice were made into the animal model of Alzheimers disease, and were randomly divided into three groups, namely, experimental group 1, experimental group 2 and control group, with 30 mice in each group. The control group was given normal saline after the success of modeling, experimental group 1 was given low-dose silybin, and experimental group 2 was given high-dose silybin. The spontaneous reaction alterna- tion rate and the level of inflammatory factors in the hippocampus of the three groups were observed. Results the total number of arm entry and spontaneous reaction alternation rate in experimental group 1 and 2 were higher than those in the control group, and the levels of interleukin-4 (IL-4) and interleukin-6 (IL-6) were lower than those in the control group (P<0.05); The total number of arm entry and spontaneous reaction alternation rate in experimental group 2 were higher than those in experimental group 1, and IL-4 and IL-6 were lower than those in experimental group 1 (P<0.05). Conclusion silybin has a good protective effect on the animal model of Alzheimers disease.

Silybin; Alzheimers disease; Animal models; Protective effect