性早熟儿童褪黑素作用研究进展-国际临床研究杂志-CSCIED科技核心评价数据库-手机版

性早熟儿童褪黑素作用研究进展

The research progress on the role of melatonin in children with precocious puberty

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DOI	10.12208/j.ijcr.20220428
刊名	国际临床研究杂志 International Journal of Clinical Research
年，卷(期)	2022, 6(8)
作者	杨祺,王爱萍*,
作者单位	昆明市第一人民医院儿童生长发育管理中心云南昆明 ;
摘要	性早熟作为常见的儿童内分泌疾病之一，在全球的发病率呈显著上升趋势。目前普遍认为光周期信号与性早熟的发病有关，这提示我们与光周期信号密切相关的褪黑素对于性早熟的发病可能存在一定的影响作用，然而具体作用及机制尚未被证实。近年来，随着国内外学者对褪黑素相关的动物模型以及人类研究的深入，发现褪黑素对人类的生殖系统、内分泌系统以及生物节律等方面均存在不同程度的调控作用，并且可能通过影响下丘脑-垂体-性腺轴、下丘脑-垂体-肾上腺轴以及KiSS1基因的表达等方式对性早熟的发病产生影响。但是，目前对于性早熟儿童褪黑素的分析研究较少，本文将对性早熟儿童褪黑素作用的研究进展进行综述。
Abstract	As one of the common endocrine diseases in children, precocious puberty has a significant increasing incidence in the world. At present, it is generally believed that photoperiod signals is related to the onset of precocious puberty, which suggests us that melatonin has a probable effect on the onset of precocious puberty, but the specific effectand mechanism have not been confirmed yet. In recent years, with the in-depth studies on melatonin-related animal models and human beings, it has been found that melatonin has different degrees of regulation on human genital system, endocrine system and biological rhythm. In addition, melatonin may affect the onset of precocious puberty by affecting the hypothalamo pituitary gonadal axis , The hypothalamic–pituitary–adrenal axis and KiSS1 gene expression. However, there are few studies on the analysis of melatonin in children with precocious puberty at present. This article will review the research progress on the role of melatonin in children with precocious puberty.
关键词	褪黑素；性早熟；儿童
KeyWord	Melatonin; Precocious puberty; Children
基金项目
页码	180-184

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引用本文

杨祺,王爱萍*. 性早熟儿童褪黑素作用研究进展 [J]. 国际临床研究杂志. 2022; 6; (8). 180 - 184.

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