血清MMP-11是小细胞肺癌诊断及评估预后的潜在生物标志物-国际临床研究杂志-CSCIED科技核心评价数据库-手机版

血清MMP-11是小细胞肺癌诊断及评估预后的潜在生物标志物

Serum MMP-11 is a potential biomarker for the diagnosis and prognosis of small cell lung cancer

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DOI	10.12208/j.ijcr.20220255
刊名	国际临床研究杂志 International Journal of Clinical Research
年，卷(期)	2022, 6(6)
作者	孙任成,吴振,张玉丽,牛国宇,于渊*,
作者单位	潍坊市中医院肿瘤外科山东潍坊 ; 潍坊医学院山东潍坊 ; 潍坊市人民医院肿瘤内科山东潍坊 ;
摘要	探讨血清基质金属蛋白酶11（MMP-11）在诊断小细胞肺癌（SCLC）及评估预后中的应用价值。方法收集110例SCLC患者和60例健康人的血清，采用酶联免疫吸附法（ELISA）检测两组间MMP-11的差异，并分析血清MMP-11与小细胞肺癌临床病理特征、化疗疗效及总生存时间（OS）的相关性。结果治疗前SCLC患者血清MMP-11水平（28.2±13.8 ng/ml）明显高于健康对照组（12.1±5.5ng/ml；p < 0.001），ROC曲线分析显示：曲线下面积（AUC）为0.849，95% CI（0.7930-0.9050），p<0.01。当截断值为18.35 ng/ml时，血清MMP-11诊断SCLC的敏感性、特异性、阳性预测值（PPV）和阴性预测值（NPV）分别为73.6%、83.3%、81.9%和76.0%。Kaplan-Meier（K-M）生存分析显示：小细胞肺癌化疗后血清MMP-11较高者（≥25ng/mL）的OS劣于较低者（<25ng/mL）的OS（中位OS：15.0 vs 23.3个月，P =0.024）。多因素Cox回归分析显示，化疗后血清MMP-11水平是OS的独立影响因素。（风险比[HR] = 1.617 [95% CI，1.126-2.648]，P =0.026）。结论血清MMP-11有望成为SCLC诊断及评估预后的一种新的血清肿瘤标志物。
Abstract	Objective To explore the value of serum matrix metalloproteinase-11 (MMP-11) in the diagnosis and prognosis of small cell lung cancer (SCLC). Methods The serum of 110 patients with SCLC and 60 healthy people were collected. The difference of MMP-11 between the two groups was detected by enzyme-linked immunosorbent assay (ELISA), and the correlation between serum MMP-11 and clinicopathological features, chemotherapy efficacy, overall survival time (OS) of small cell lung cancer was analyzed. Results The level of serum MMP-11 in SCLC patients before treatment (28.2 ± 13.8 ng/ml) was significantly higher than that in healthy control group (12.1 ± 5.5 ng/ml; P < 0.001). ROC curve analysis showed that the area under the curve (AUC) was 0.849, 95% CI (0.7930-0.9050), P < 0.01. When the cutoff value was 18.35 ng/ml, the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of serum MMP-11 in the diagnosis of SCLC were 73.6%, 83.3%, 81.9% and 76.0%, respectively. Kaplan Meier (K-M) survival analysis demonstrated that the OS of patients with high serum MMP-11 (≥ 25ng/ml) was worse than that of patients with low serum MMP-11 (< 25ng/ml) (median OS: 15.0 vs 23.3 months, P=0.024). Multivariate Cox regression analysis indicated that the level of serum MMP-11 after chemotherapy was an independent influencing factor of OS. (hazard ratio [HR] = 1.617 [95% CI, 1.126-2.648], P = 0.026). Conclusion Serum MMP-11 could become a new serum tumor marker for the diagnosis and prognosis of SCLC in prospect.
关键词	小细胞肺癌；基质金属蛋白酶11；血清生物标志物；化疗效果；预后
KeyWord	Small cell lung cancer; matrix metalloproteinase-11; serum biomarkers; chemotherapy effect; prognosis
基金项目
页码	44-51

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孙任成,吴振,张玉丽,牛国宇,于渊*. 血清MMP-11是小细胞肺癌诊断及评估预后的潜在生物标志物 [J]. 国际临床研究杂志. 2022; 6; (6). 44 - 51.

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