International Journal of Obstetrics and Gynecology

Objective To explore the quality of life assessment and screening strategies in patients with per- sistent HR-HPV infection. Methods From October 2019 to April 2022 in our hospital, 128 patients with persistent HR-HPV infection and 130 patients without HPV infection were selected. Quality of life (QOL) and quality of sexual life (SLQQ) questionnaires were evaluated, and 128 patients with persistent HR-HPV infection were sub- jected to HPVDNA typing, HPVE6/E7mRNA, P16/Ki67 detection, TCT detection and cervical biopsy pathological examination under colposcopy; The scores of the four groups of patients with persistent HR-HPV infection were statistically analyzed; and the positive and negative coincidence rates of HPVE6/E7mRNA and P16/Ki67 were statistically analyzed based on the pathological results of cervical biopsy. Results Compared with those without HPV infection, patients with persistent HR-HPV infection had significantly lower scores of quality of life and sexual life, and significantly higher scores of depression and anxiety; among the patients, age>35 years, infection time of more than 5 years, infection of HPV16/18 Compared with the other corresponding stages, patients with higher SAS and SDS scores, lower QOL and SLQQ scores (P<0.05), and patients with education level below a junior college or above had no significant difference in the four scores (P>0.05). The positive and negative coinci- dence rates of HPVE6/E7 mRNA were higher than those of HPVDNA, and the positive and negative coincidence rates of P16/Ki67 were higher than those of TCT (P<0.05). The coincidence rate was higher than that of HPV DNA+TCT combined detection (P<0.05). Conclusion The quality of life and sexual life quality of patients with persistent HR-HPV infection are significantly decreased, and they have different degrees of depression and anxiety. Among them, patients with older age, longer infection time, and HPV16/18 infection have more obvious decline in quality of life, and symptoms of depression and anxiety. heavier. The single and combined detections of HPV E6/E7mRNA and P16/Ki67 have high positive and negative coincidence rates, which can be used as effective prediction and screening methods for HR-HPV persistent infection.

HR-HPV; persistent infection; Quality of life; Assessment; Screening