Journal of International Psychiatry

【Abstract】 Objective: To explore effect of methyl prednisolone combined with gamma globulin on psychological status and prognosis in the treatment of children with viral encephalitis. Methods: 90 cases of viral encephalitis in our hospital from January 2013 to May 2015 were randomly divided into experimental group and the control group, control group using conventional acyclovir and dexamethasone treatment, treatment group on the basis of conventional treatment of vein increased with prednisolone and gamma globulin. The psychological state and movement function before and after treatment were evaluated with Parents Symptom Quenstionaire (PSQ), FugI-Meyer Assessment (FMA) and Ashworth spasticity scale (ASS). At the same time, the adverse reaction were surveyed (P>0.05). Results: After treatment, each single factor of PSQ of experimental group was lower than that of control group (P<0.01), the total effective rates of experimental group and control group were 91.11% and 73.33%, respectively, the difference reached statistical level (P<0.01), there was no statistical difference in adverse reaction rate between the two groups (P>0.05). Conclusion: Methyl prednisolone combined with gamma globulin has good effect in improving psychological status in treatment of children with viral encephalitis patients, and has good feasibility and security, therefore it is worth of clinical application.

【Key words】 Viral encephalitis; Psychological state; Movement disorders; Methyl prednisolone; Gamma globulin