伴有失眠症状的抑郁症患者NPY和SP水平的变化研究-国际精神病学杂志-CSCIED科技核心评价数据库-手机版

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伴有失眠症状的抑郁症患者NPY和SP水平的变化研究

Serum level of neuropeptide Y and substance P among depressive patients accompanied by insomnia

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刊名	国际精神病学杂志 Journal of International Psychiatry
年，卷(期)	2016, 43(5)
作者	杨媛*,胡明,葛红敏,田丽,
作者单位	天津市安定医院 ;
摘要	【摘要】探讨伴有失眠症状的抑郁症患者NPY和SP水平的变化。方法选取符合纳入标准的人群为研究对象，依据PSQI、PHQ-9及诊断性访谈将被试分为四组：既无抑郁又无失眠症状组，仅有抑郁无失眠症状组，仅有失眠又无抑郁组，伴有失眠症状的抑郁症组，每组30例，比较四组的NPY及SP水平。以NPY及SP为因变量，以PSQI、PHQ-9为自变量进行相关性分析。结果伴有失眠症状的抑郁症患者NPY的浓度为（5.93±1.36）ug/mL低于对照组，SP浓度为（6.39±2.14）ug/mL高于对照组，差异具有统计学意义（P﹤0.01）。伴有失眠症状的抑郁症患者的SP含量与PSQI、PHQ-9均不相关，NPY含量与PSQI呈负性相关，且具有统计学意义（r=-0.31, P=0.026）。结论相对于对照组而言，伴有失眠症状的抑郁症患者NPY水平较低，SP水平较高。
Abstract	【Abstract】 Objective To investigate the level of NPY and SP among depressive patients accompanied by insomnia. Methods 120 adults were recruited and was divided into four groups according to PSQI、PHQ-9 and diagnose interview: no depressive symptoms and no insomnia, depressive symptoms and no insomnia, no depressive symptoms and insomnia, depressive symptoms and insomnia. Compare the level of NPY and SP of the four groups. Interrelations between the variables were tested using Pearson correlation analyses. Results The level of NPY in depressive symptoms and insomnia group is（5.93±1.36）ug/mL lower than control group. The level of SP is（6.39±2.14）ug/mL higher than control group. The statistics is significant (P﹤0.01). The SP was not correlated with PSQI and PHQ-9. The NPY was significantly negativity correlated with PSQI(r=-0.31, P=0.026 ). Conclusion The level of NPY is low, the SP is high among depressive patients accompanied by insomnia.
关键词	【关键词】抑郁；失眠；神经肽Y；P物质
KeyWord	【Key words】 Depression; Insomnia; Neuropeptide Y ; Substance P
基金项目
页码	781-783

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杨媛*,胡明,葛红敏,田丽. 伴有失眠症状的抑郁症患者NPY和SP水平的变化研究 [J]. 国际精神病学杂志. 2016; 43; (5). 781 - 783.

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