| 摘要 |
观察首发精神分裂症（SZ ）患者血清叶酸、同型半胱氨酸（ Hcy ）水平和认知功能情况，探讨血清叶酸、Hcy水平与认知功能的相关性。方法 以2014年3月-2015年6月在我院接受治疗的45例首发精神分裂症患者为观察对象，同时选取50例健康成年人作为对照组。观察两组患者血清叶酸,， Hcy水平和认知功能情况，采用Pearson相关分析法分析血清叶酸, Hcy水平与认知功能的相关性。结果首发sz组患者的叶酸水平明显低于对照组，而Hcy水平明显高于对照组，差异具有统计学意义；首发sz组患者的定向力、瞬时记忆和注意力计算力以及词语即刻记忆、延迟回忆等得分均低于对照组，差异具有统计学意义（P<0.05）；叶酸水平与患者的定向力、瞬时记忆和注意力计算力等正相关，Hcy水平与上述指标负相关，而叶酸、Hcy水平均与语言能力、视空间觉和词语即刻记忆无明显相关关系。结论 首发sz患者血清叶酸水平较低、Hcy水平较高，且上述指标与患者的认知功能密切相关。
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| Abstract |
Objective To observe the serum levels of folic acid, Hcy and cognitive function in patients with first episode of SZ, and to explore the relationship between serum folate, Hcy level and cognitive function. Methods 45 patients with schizophrenia in our hospital from March 2014 to June in our hospital were selected as the study subjects, and 50 healthy adults were selected as the control group. Methods 45 patients with schizophrenia treated in our hospital from March 2014 to June 2015 were selected as the study subjects, and 50 healthy adults were selected as the control group. The serum levels of folic acid, Objective To observe the serum levels of folic acid, Hcy and cognitive function in patients with first episode of SZ, and to explore the relationship between serum folate, Hcy level and cognitive function. Methods 45 patients with schizophrenia in our hospital from March 2014 to June in our hospital were selected as the study subjects, and 50 healthy adults were selected as the control group. Methods 45 Forty-five patients with schizophrenia treated in our hospital from March 2014 to June 2015 were selected as the study subjects, and 50 healthy adults were selected as the control group. The serum levels of folic acid, Hcy and cognitive function were observed in two groups. The correlation between serum folate, Hcy level and cognitive function was analyzed by Pearson correlation analysis. Results The level of folic acid in the first group SZ patients was significantly lower than that of the control group, while the Hcy level was significantly higher than that of the control group, the difference was statistically significant; In the first group , tThe scores of directional force, instantaneous memory, attention force , immediate memory and delayed recall of SZ group were significantly lower than those of the control group (P<0.05), the directional force, instantaneous memory and attention force , as well as the immediate memory and delayed recall; The level of Folic acid and patient orientation, instantaneous memory and attention calculation was related, Hcy level and the indicators were negatively correlated, and folic acid, homocysteine (Hcy) level were language ability, visual and spatial perception and word immediate memory with no obvious correlation. Conclusions The level of serum folate and Hcy in the patients with first episode of SZ wereare relatively low, and the above indexes were closely related to the cognitive function of the patients.
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