Journal of International Psychiatry

Objective To explore the efficacy of cognitive function in schizophrenia patients treated by aripiprazole combined with cognitive intervention. Methods A total of 92 schizophrenia patients were randomly divided into two groups: 46 study group(treated with aripiprazole combined with cognitive intervention) and 46 control group(treated with aripiprazole only) for 12 weeks. Cognitive function was assessed by wisconsin card sorting test(WCST), continuous performance test(CPT), trail making test(TMT), category fluency(CF), hopkins verbal learning test-revised(HVLT-R) and wechsler memory scale-Ⅲ(WMS-Ⅲ). Treatment emergent symptom scale(TESS) was assessed side effects during treatment. Results In the treatment of 12th weekend, the scores of WCST, CPT, TMT, CF, HVLT-R, WMS-Ⅲ in both groups were all significantly better than pre- treatment(P<0.01), and study group was significantly superior to control group(P<0.05 or P<0.01). Two groups shown no significant difference in side effects(P>0.05). Conclusion Aripiprazole combined with cognitive intervention has better efficacy to improve cognitive function of schizophrenia than single aripiprazole.

Aripiprazole; Cognitive Intervention; Cognitive Function; Schizophrenia