Journal of International Psychiatry

【Abstract】Objectives: To investigate the effects of comprehensive intervention combined with antipsychotics for treatment of schizophrenia patients in community and influencing factors affecting social function in patients. Methods: 160 patients with stable schizophrenia in citys community were chosen. According to the principle of completely random, all patients were divided into control and intervention groups, each group 80 cases. In the control group patients received conventional antipsychotics, while in the intervention group patients received comprehensive intervention based on control group. The scores of Positive and Negative Syndrome Scale (PANSS), Social Disability Screening Schedule (SDSS) and Morning Side Rehabilitation Status Scale (MRSS) were observed and compared between the two groups. Results: After 3 and 12 months of the intervention, the PANSS, SDSS, MRSS scores in intervention group were significantly lower than those in the control group, the differences were statistically significant (P <0.05). Compared to the same group before intervention, the above scores were significantly lower after intervention, the differences were statistically significant (P <0.05). Multiple stepwise regression showed that, whether the intervention, the PANSS score and MRSS score before intervention, duration were have a linear regression with social functional recovery, in which the MRSS scores before intervention of the maximum effect. Conclusion: The effect of comprehensive intervention combined with antipsychotics for treatment of schizophrenia patients in community is significant, which can effectively control psychotic symptoms, improve patients’ recovery and enhance its social function.

【Key words】Schizophrenia; Community; Comprehensive intervention; Social functions