International Research in Chinese Medicine

Objective To explore the value of using the modified Xiaoshanzhi Fuling Decoction from “The Essentials of the Jingui Classic” for treating schizophrenia patients with “epilepsy” as diagnosed by traditional Chinese medicine (whose main symptoms are negative symptoms). Methods Fifty patients with schizophrenia caused by internal dampness (from September 2023 to September 2025) admitted to our hospital were selected and randomly divided into two groups. The control group (25 cases) was treated with conventional antipsychotic Western drugs (such as olanzapine and risperidone), while the observation group (25 cases) was treated with the combination of Xiao Banxia Jia Fu Ling Decoction modification on the basis of the control group. The evaluation was conducted based on the TCM syndrome score, Positive and Negative Syndrome Scale (PANSS) score, clinical efficacy and safety. Results After treatment, the TCM syndrome scores and PANSS negative symptom scores of the observation group were both lower than those of the control group (P < 0.05). The clinical total effective rate of the observation group (92.00%) was higher than that of the control group (68.00%), (P < 0.05). There was no significant difference in the incidence of adverse drug reactions between the two groups (P > 0.05). Conclusion The adjunctive use of Xiao Banxia Jia Fuling Decoction modification in patients with epilepsy can improve the traditional Chinese medicine syndromes and core negative symptoms, enhance the therapeutic effect, and has good safety.

Schizophrenia (with predominant negative symptoms); Jingui yaolue; Xiao banxia jia fu ling decoction