| Abstract |
[Abstract] Objective: To explore the safety and efficacy of Silibin Meglumine tablets in treatment with liver injury induced by anti neuropathy.Methods: A total of 128 cases of liver injury patients who induced by anti neuropathy accorded to the random number table method was divided into observation group 64 cases and control group 64 cases,observation group was treated with Silibin Meglumine tablets, 200mg/times, 3 times/d.Control group oral Huganning tablets,1.75g/times, 3 times/d, two groups of patients were treated 3 months for 1 courses.Liver function and blood urea nitrogen (BUN) and creatinine (Cr) levels were monitored in two groups of patients before and after 1 months, 3 months and 6 months of treatment respectively,and clinical symptoms,adverse reactions incidence of two groups were recoreded.Results:The total effective rate of observation group was 93.8% (60/64), the control group total effective rate was 89.1% (57/64), there was no significant difference in the total effective rate between the two groups (P>0.05).There was no significant difference in TBIL between the two groups before and after treatment (P>0.05),after treatment two groups ALT, AST, γ-GT showed a decreased trend,and after 1 months and 3 months the ALT, AST, γ-GT in observation group of treatment was significantly lower than those in the control group in same period(P<0.05).There was no significant difference in BUN between the two groups before and after treatment (P>0.05),after treatment two groups Cr showed a decreased trend,and after 1 months and 3 months the Cr in observation group was significantly lower than those in the control group in same period(P<0.05).After 6 months of treatment, the incidence of uncomfortable in the hepatic region,large hepatic in the observation group was significantly lower than that in the control group (P<0.05),two groups of patients with fatigue, anorexia, abdominal distension with no significant differences (P>0.05).Conclusion:Silibin Meglumine tablets and Huganning tablets can improve liver function in patients with liver injury induced by anti neuropathy,Silibin Meglumine tablets reduces AST,ALT level are faster, clinical symptoms improvement are more obvious, with high safety,and worthy of clinical promotion.
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