International Journal of Clinical Research

Objective To investigate the clinical efficacy and safety of CO₂ fractional laser therapy for facial skin photoaging. Methods A total of 80 patients with facial skin photoaging who visited the dermatology department of our hospital from June 2024 to June 2025 were selected and randomly divided into an observation group and a control group using a random number table. The observation group received CO₂ fractional laser therapy, while the control group received conventional topical medications combined with intense pulsed light (IPL) therapy. The total effective rate of wrinkle improvement, skin elasticity recovery score, area of pigment regression, and incidence of adverse reactions were compared between the two groups. Results The observation group showed significantly higher rates of total effective wrinkle improvement, skin elasticity recovery score, and area of pigment regression compared to the control group. Additionally, the incidence of adverse reactions was lower in the observation group (P<0.05). Conclusion CO₂ fractional laser therapy demonstrates significant efficacy in treating facial skin photoaging, effectively improving wrinkles, restoring skin elasticity, and reducing pigmentation. It also exhibits high safety, making it worthy of clinical promotion and application.

CO₂ fractional laser; Facial skin photoaging; Clinical efficacy; Skin elasticity; Wrinkle improvement; Safety