International Journal of Clinical Research

Objective To explore the clinical effect of Xigua Frost Spray combined with Cydiodine Lozenges on the pain degree and ulcer healing of patients with oral ulcers. Methods A total of 86 patients with oral ulcers admitted to our hospital from October 2023 to October 2025 were selected and randomly divided into two groups using a random number table, with 43 cases in each group. The control group was treated with Cydiodine Lozenges, while the observation group was treated with Xigua Frost Spray in addition. The clinical recovery effect, Visual Analogue Scale (VAS) score, and the time for clinical symptom relief were compared between the two groups. Results The total effective rate of the observation group was 97.67%, which was higher than that of the control group (83.72%, P < 0.05). After treatment, the VAS score of the observation group was lower than that of the control group (P < 0.05). The ulcer healing time, redness and swelling disappearance time, and burning pain disappearance time of the observation group were shorter than those of the control group (P < 0.05). Conclusion The combination of Xigua Frost Spray and Cydiodine Lozenges in the treatment of oral ulcers can more effectively relieve pain, promote ulcer healing, and shorten the time for related symptom relief, and its clinical efficacy is superior to that of Cydiodine Lozenges alone.

Oral ulcers; Xigua frost spray; Cydiodine lozenges; Visual analogue scale; Clinical efficacy