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Abstract: Objective To investigate the postoperative analgesic effect and anxiety influence of Parecoxib for patients with trans-temporal and trans-sphenoid craniotomy. Methods 90 patients undergoing elective craniotomy (trans-temporal and trans-phenoid) were enrolled,randomly divided into group A, group B and group C,30 cases in each. 40mg PS was given intravenously at 20 minutes before operation in group A, 40mg PS was given intravenously before closure of dura mater in group B, 10mL saline was given intravenously before closure of dura mater in group C.The pain scores (VAS), anxiety scores (SAS), plasma cortisol (Cor) ,serum β- endorphin (β-EP) and postoperative adverse reactions in three groups were monitored and compared at before operation (T0) and 2h (T1), 6h (T2), 12h (T3), 24h (T4),48h (T5)after operation.Results At each time point of T1~T4,the VAS, SAS scores, β-EP and Cor in group A and B were significantly lower than those in group C(P<0.05),and group A were significantly lower than those in group B (P<0.05); The β-EP and Cor at T5 in group A were significantly lower than those in group B and C(P<0.05); Within 48h after operation,the utilization of Rotundine and incidence of anxiety, restlessness in group A and B was significantly lower than that in group C (P<0.05). Conclusion PS has nalgesic and anxiolytic effect on patients after trans-temporal and trans-sphenoid craniotomy,can reduce the stress reaction,and it shows better result if administrated before operation.
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