International Journal of Clinical Research

Objective To investigate the effects of sevoflurane combined anesthesia on stress response and hemodynamic parameters in patients undergoing laparoscopic cholecystectomy. Methods 120 patients who underwent laparoscopic cholecystectomy from January 2023 to June 2025 were randomly divided into an observation group (anesthesia with sevoflurane combined with remifentanil) and a control group (anesthesia with propofol combined with remifentanil). Monitor the serum cortisol (Cor), norepinephrine (NE), heart rate (HR), and mean arterial pressure (MAP) levels of two groups of patients before anesthesia, after surgery, and during extubation. Results The levels of Cor, NE, HR, and MAP in the observation group at T1 and T2 were significantly lower than those in the control group, and the differences were statistically significant (P<0.05). There was no significant difference in various indicators between the two groups of patients at T0 (P>0.05). Conclusion Sevoflurane combined anesthesia can more effectively suppress stress response during laparoscopic cholecystectomy, maintain hemodynamic stability, and may provide reference for optimizing anesthesia plans in clinical practice.

Sevoflurane; Laparoscopic cholecystectomy; Stress response; Hemodynamics; Cortisol; Norepine-phrine