International Journal of Clinical Research

Objective To investigate the effect of intranasal administration of dexmedetomidine and midazolam for preoperative sedation in children undergoing adenoidectomy. Methods 76 pediatric patients who underwent adenoidectomy in the hospital from March 2022 to May 2023 were selected as the study subjects and randomly divided into an observation group (intranasal administration of dexmedetomidine) and a control group (intranasal administration of midazolam). The sedative effect, respiratory and circulatory function indicators, and incidence of adverse reactions were compared between the two groups. Results The sedative effect of the observation group (4.28±0.31 points) was higher than that of the control group, and the heart rate and airway pressure (87.63±5.15 beats/min, 17.98±0.85cmH₂O) were higher than those of the control group. The end tidal carbon dioxide pressure and arterial oxygen saturation (29.67±3.73P_ETCO₂, 97.63±5.14SpO₂) were lower than those of the control group, and the incidence of adverse reactions (2.63%) was lower than that of the control group (P<0.05). Conclusion Nasal administration of dexmedetomidine has a significant effect on preoperative sedation in children undergoing adenoidectomy, which can effectively improve the sedative effect, stabilize the patient's respiratory and circulatory function indicators, and reduce the incidence of adverse reactions. It is worthy of wide promotion and application.

Dexmedetomidine; Midazolam; Nasal administration of medication; Pediatric adenoidectomy; Preoperative sedation