International Journal of Clinical Research

Objective To investigate the value of high-frequency color Doppler ultrasound in the differential diagnosis of thyroid cancer. Methods A total of 30 patients suspected of having thyroid cancer were selected as the sample from August 2021 to August 2024. All patients underwent conventional ultrasound examination during this period, followed by high-frequency color Doppler ultrasound examination. Pathological biopsy results were then used as a reference to observe the examination outcomes and analyze their diagnostic efficacy, followed by identifying imaging features. Results The true positive detection rate in surgical biopsy was 43.33% (13/30), and the true negative detection rate was 56.67% (17/30); for conventional ultrasound, the true positive detection rate was 23.33% (7/30) and the true negative detection rate was 43.33% (13/30); for high-frequency ultrasound, the true positive detection rate was 40.00% (12/30) and the true negative detection rate was 63.33% (17/30). In the analysis of diagnostic specificity, sensitivity, and accuracy, high-frequency color Doppler ultrasound (92.31%, 100.00%, 96.67%) was significantly higher, whereas conventional ultrasound (53.85%, 76.47%, 66.67%) was lower, P<0.05. Imaging features showed that thyroid cancer patients had higher rates of blurred margins (61.54%), low/extremely low echogenicity (92.31%), nodule length-to-width ratio ≥1 (69.23%), irregular shape (61.54%), microcalcifications (61.54%), and type III blood flow pattern (38.46%) than benign thyroid lesions, P<0.05. Conclusion High-frequency color Doppler ultrasound has high diagnostic efficacy, with clear imaging features, which can improve the true positive detection rate of thyroid cancer.

Thyroid cancer; Diagnostic efficacy; Imaging features; High-frequency color Doppler ultrasound