PM2.5对高血压的跨代影响及可能机制

The transgenerational effects of PM2.5 on hypertension and possible mechanisms

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DOI 10.12208/j.ijcr.20250571
刊名
International Journal of Clinical Research
年,卷(期) 2025, 9(12)
作者
作者单位

重庆市中医院心血管病科 重庆

摘要
高血压是环境和遗传因素共同作用的结果,PM2.5可致高血压发生进展是近年研究的热点,同时孕期或父源PM2.5暴露对血压及心血管系统的影响越来越受到人们的关注,其机制可能涉及氧化应激、宫内环境不良、表观遗传等跨代遗传学。本文重点就PM2.5对高血压的影响、孕期PM2.5暴露对子代高血压的影响、父源性PM2.5暴露对子代高血压的影响以及可能的表观遗传机制进行综述,为明确PM2.5导致高血压的发病机制提供理论基础,同时也为高血压的个体化治疗提供新的研究思路。
Abstract
Hypertension is a result of the combined effects of environmental and genetic factors. The progression of hypertension caused by PM2.5 has been a hot topic in recent studies, while the impact of prenatal or paternal PM2.5 exposure on blood pressure and cardiovascular systems are increasingly attracted public attention. The mechanisms may involve transgenerational inheritance through oxidative stress, adverse intrauterine environments, DNA methylation, lncRNAs, and so on. This article focuses on reviewing the effects of PM2.5 on hypertension, including its impact on offspring's hypertension during pregnancy, paternal PM2.5 exposure, and potential epigenetic mechanisms. It aims to provide a theoretical foundation for clarifying the pathogenesis of PM2.5-induced hypertension and offer new research perspectives for personalized hypertension treatment.
关键词
PM2.5;高血压;表观遗传;跨代遗传
KeyWord
PM2.5; Hypertension; Epigenetics; Transgenerational inheritance
基金项目
页码 52-58
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蒋嘉辉, 刘丹, 芦茜. PM2.5对高血压的跨代影响及可能机制 [J]. 国际临床研究杂志. 2025; 9; (12). 52 - 58.

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