International Journal of Clinical Research

Objective To observe the effects of three anticoagulation regimens, namely unfractionated heparin, low - molecular - weight heparin, and sodium citrate, on filter coagulation in severe blood purification and the effects of nursing interventions. Methods A total of 176 patients undergoing severe blood purification from January 2024 to June 2025 were selected and divided into Group A (unfractionated heparin, 58 cases), Group B (low - molecular - weight heparin, 58 cases), and Group C (sodium citrate, 60 cases). Targeted nursing was implemented for all groups, and indicators such as filter coagulation were compared. Results The incidence of filter coagulation in Group C (6.67%) was lower than that in Group A (31.03%) and Group B (17.24%). The service life of the filter in Group C (45.89 ± 6.02 h) was longer than that in Group A and Group B, and the incidence of bleeding in Group C (3.33%) was lower than that in Group A and Group B (P < 0.05). Conclusion Anticoagulation with sodium citrate combined with nursing intervention can reduce the risks of filter coagulation and bleeding, and prolong the service life of the filter.

Severe blood purification; Anticoagulation regimens; Filter coagulation; Nursing intervention