International Journal of Clinical Research

Objective To improve the accuracy of pathological diagnosis and differential diagnosis of pancreatic intraductal papillary tumor (IPMN). Methods from April 2024 to March 2025, 40 cases of intraductal papillary tumor of pancreas in our hospital were selected and randomly divided into experimental group and control group, with 20 cases in each group. The pathological specimens were stained with he to observe the histological morphology and cell characteristics. The expression of MUC1, MUC2, MUC5AC, CDX -2 and other markers were detected by immunohistochemical staining, and the characteristic pathological differences between intraductal papillary tumor of pancreas and ductal adenocarcinoma, mucinous cystic tumor, solid pseudopapillary tumor were compared. Results IPMN tumor cells showed intraductal papillary growth with relatively small cell atypia, high expression of MUC5AC and negative expression of MUC1; It is significantly different from pancreatic ductal adenocarcinoma, serous cystadenoma and other diseases in growth mode, cell morphology, and immunohistochemical marker expression. Conclusion the key indicators and differential points of pathological diagnosis of pancreatic ductal papillary tumor can provide reference for clinical accurate diagnosis, and can effectively improve the diagnostic accuracy and efficiency of pancreatic ductal papillary tumor.

Intraductal papillary tumor of the pancreas; Pathological diagnosis; Differential diagnosis