International Journal of Clinical Research

Objective To observe the clinical efficacy of Xintongshu spray combined with conventional Western medicine treatment for coronary artery disease patients with arrhythmia and electrocardiogram abnormalities. Methods 298 patients admitted from September 2023 to August 2025 were included, divided into a combined treatment group and a control group, with 149 patients in each group. The treatment course was 1 week. Changes in angina attacks, electrocardiogram improvement, cardiac function, vital signs, and phlegm-heat, heat-toxin, and blood stasis scores were compared between the two groups. Results The effective rate of angina in the combined treatment group was 78.52%, which was higher than that in the control group (55.70%) (P<0.001); the effective rate of electrocardiogram was 72.48% vs 51.68% (P<0.001). After treatment, the combined treatment group showed a significantly higher LVEF (58.32±4.21)% compared to the control group (53.06±4.35)% (P<0.001), with more significant improvements in LVESD, LVDD, and CI (P<0.05). The combined treatment group also showed a greater reduction in phlegm-heat, heat-toxin, and blood stasis scores compared to the control group (P<0.01). Conclusion The combination of Xintongshu spray and conventional treatment can significantly improve angina symptoms, ECG abnormalities, and cardiac function, demonstrating advantages and good safety.

Xintongshu spray; Coronary heart disease; Arrhythmia; Electrocardiogram