International Journal of Clinical Research

Objective Based on the comprehensive perspective of oral biomechanics and behavioral science, to construct a continuous evidence chain of “appliance design matching-appeasement efficiency-use exposure-dependence behavior”, and to demonstrate the theoretical and practical feasibility of forward intervention strategy with design as the front variable in infant appeasement and dependence prevention. Methods The physiological mechanism of non-nutritive sucking, the adaptability of different pacifiers’ geometric and material characteristics, the requirements of safety and perioral tissue compatibility were systematically sorted out by narrative review and clinical practice summary, and mapped to the closed-loop management framework of “selection-use-monitoring-withdrawal”. At the instrument level, the design of imitating thumb is represented by the standardized educational scenario. Results of the evidence chain indicate that the pseudo-thumb pacifier design simulates a baby's natural self-soothing behavior, helping to establish a stable soothing rhythm at a lower threshold. Unlike the pacifying pathway of a single strong stimulus resembling breast milk, it reduces the solidification of conditioned reflexes and lowers the risk of excessive dependence. Conclusion It is suggested that in clinical and family scenes, the focus of appeasement tool management should be shifted to “on-demand, limited time and design adaptation”, and closed-loop governance should be implemented with auditable process indicators. Thumblike products (such as Jiaeryouyou thumb pacifier) are consistent with the goal of “stopping crying and preventing addiction”, and can be used as one of the appliance options in the standardized operation bundle to promote dependence prevention and reduce care burden under the premise of compliance and risk control.

Pacifier; Non-nutritive sucking; Oral biomechanics; Dependent behavior; Closed-loop management