International Journal of Clinical Research

Objective To investigate the clinical efficacy of amniotic membrane transplantation combined with heparin in the treatment of moderate to severe ocular chemical burns and acute phase of thermal burns. Methods Eighty patients with moderate to severe ocular chemical burns or acute phase of thermal burns admitted from July 2022 to May 2024 were selected. They were divided into the observation group (33 cases, 40 eyes, treated with amniotic membrane transplantation + conventional treatment + heparin) and the control group (33cases, 40 eyes, treated with conventional treatment only). The ocular surface healing time, corneal transparency, and complication rate were compared between the two groups. Results The ocular surface healing time of the observation group was (18.25±3.12) days, which was shorter than that of the control group [(26.78±4.56) days] (t=10.234, P=0.000). After 1 month of treatment, the corneal transparency score of the observation group was (2.15±0.67) points, which was higher than that of the control group [(1.32±0.54) points] (t=6.897, P=0.000). The complication rate of the observation group was 7.50%, which was lower than that of the control group (25.00%) (χ²=5.165, P=0.023). Conclusion Amniotic membrane transplantation combined with heparin can accelerate the healing of ocular burns in the acute phase, improve corneal transparency, and reduce the risk of complications, which is worthy of clinical promotion.

Amniotic membrane transplantation; Moderate to severe ocular chemical burns; Thermal burns; Acute phase; Clinical efficacy