International Journal of Clinical Research

Objective To observe the effect of collagen combined with hyaluronic acid injection in patients undergoing orbital annual lightening treatment. Methods A total of 60 patients who underwent annual orbital lightening treatment in our hospital were included (period from June 2023 to June 2025). Divide all patients into two groups, including a control group (n=30, treated with hyaluronic acid injection) and an observation group (n=30, treated with collagen combined with hyaluronic acid injection). Evaluate the therapeutic effect of two groups comprehensively based on the tear groove status and periorbital skin status. Results After treatment, the scores of all dimensions of the Tear Trough Rating Scale (TTRS) in the observation group decreased compared to the control group (P<0.05). After treatment, the observation group showed an improvement in skin laxity and crow's feet improvement scores compared to the control group (P<0.05). Conclusion The application of collagen combined with hyaluronic acid injection in the annual orbital lightening treatment of patients can improve the tear troughs and skin condition.

Periorbital rejuvenation; Collagen protein; Hyaluronic acid injection