International Journal of Clinical Research

Objective To investigate the clinical efficacy of the combined use of ceftriaxone sodium and benzathine penicillin in the treatment of latent syphilis. Methods This study selected 200 patients with latent syphilis admitted to our hospital from June 2022 to October 2024 as research subjects. They were randomly assigned using a random number table to the control group (100 cases, treated with benzathine penicillin) and the study group (100 cases, treated with a combination of ceftriaxone sodium and benzathine penicillin). The treatment effects of the two groups were then compared. Results There was no statistically significant difference in the serum Trust seroconversion rate and the incidence of adverse reactions between the two groups of patients after 3 months of treatment (P>0.05). However, after 9 months and 12 months of treatment, the serum Trust seroconversion rate in the study group was higher than that in the control group, and the difference was statistically significant (P<0.05). Conclusion Implementing a combined treatment regimen of ceftriaxone sodium and benzathine penicillin for patients with latent syphilis can shorten the time for Trust titers to decrease.

Ceftriaxone sodium; Benzylpenicillin; Latent syphilis; Serum Trust seroconversion rate