International Journal of Clinical Research

Objective To investigate the specific effects of transcranial magnetic stimulation (rTMS) combined with olanzapine in the clinical treatment of auditory hallucinations in schizophrenia. Methods A total of 78 patients with schizophrenia and auditory hallucinations symptoms, who visited Xiangyang Anding Hospital from June 2023 to June 2024, were enrolled. They were randomly divided into an olanzapine group, an rTMS combined with olanzapine control group, and an observation group, with 39 cases in each group. All indicators were compared. Results No significant differences were observed between groups in the PANSS scale and WMS scores (P>0.05). However, post-treatment results showed significant differences (P<0.05), with the observation group achieving lower PANSS scores and higher WMS scores. The overall response rate also demonstrated significant intergroup differences (P<0.05), with the observation group showing a higher overall response rate. Conclusion To ensure the more stable condition of patients with schizophrenia auditory hallucination, it is suggested to use transcranial magnetic stimulation and olanzapine in combination, which is beneficial to the improvement of patients’ cognitive impairment.

Transcranial magnetic stimulation; Olanzapine; Schizophrenia; Auditory hallucinations; Cognitive impairment