International Journal of Clinical Research

Objective To explore the risk factors of adjacent vertebral fractures in elderly female patients with osteoporotic vertebral compression fractures (OVCF) after conservative treatment. Methods A total of 147 elderly female patients with OVCF undergoing conservative treatment were selected and divided into the fracture group (36 cases) and the non-fracture group (111 cases) based on whether adjacent vertebral fractures occurred. Univariate analysis was used to compare the differences in clinical data between the two groups, and meaningful factors were included in multivariate Logistic regression analysis to screen for risk factors. Results Univariate analysis showed that there were statistically significant differences between the two groups in terms of fracture compression degree, T-value of bone mineral density at follow-up visit, T-value of bone mineral density change, and the use of zoledronic acid and parathyroid hormone analogues (P<0.05). Multivariate Logistic regression analysis showed that the degree of fracture compression, changes in bone mineral density, and the use of parathyroid hormone analogues were independent risk factors for adjacent vertebral fractures. Conclusion The degree of fracture compression, changes in bone mineral density, and the use of parathyroid hormone analogues are closely related to adjacent vertebral fractures after conservative treatment of OVCF in elderly women. Targeted clinical intervention is needed to reduce the risk of fractures.

Elderly women; Osteoporotic vertebral compression fractures; Conservative treatment; Adjacent vertebral fractures; Risk factors