International Journal of Clinical Research

Objective To explore the effect of Shegan Mahuang Decoction on interleukin-35 (IL-35) in asthma patients. Methods Thirty patients with cold asthma who visited the Department of Pulmonary Disease at Qijiang District Traditional Chinese Medicine Hospital in Chongqing from January 2025 to December 2025 were included. They were randomly divided into a Western medicine group (n=15) and a Shegan Mahuang Decoction group (n=15), and the efficacy of the two groups was evaluated. Results After treatment, the scores of traditional Chinese medicine (TCM) syndromes in both groups decreased compared to before treatment, while the levels of lung function indicators and IL-35 indicators increased compared to before treatment. The scores of TCM syndromes and the difference before and after treatment in the Shegan Mahuang Decoction group were significantly lower than those in the Western medicine group, while the levels of lung function indicators and IL-35 indicators and the difference before and after treatment were significantly higher than those in the Western medicine group (P<0.01). Conclusion Shegan Mahuang Decoction can significantly increase the level of IL-35 in patients with cold asthma, improve symptoms and lung function, and is worthy of promotion.

Shegan Mahuang Decoction; Asthma; Treatment effect; Interleukin-35; IL-35