International Journal of Clinical Research

Objective To clarify the clinical value of combined detection of Helicobacter pylori (HP), serum tumor markers and HER-2 in the diagnosis of gastric cancer. Methods Sixty patients with gastric cancer were selected as the observation group, and another 60 patients with benign gastric lesions and 60 healthy individuals undergoing physical examinations were set as the control group. All the research subjects underwent HP antibody typing and serum tumor marker detection. In the observation group, postoperative tissue HER-2 immunohistochemical detection was added, and the diagnostic efficacy was analyzed through ROC curve. Results The infection rate of HP, the level of tumor markers and the positive expression rate of HER-2 in the observation group were significantly higher than those in the control group. Moreover, the level of tumor markers and the positive rate of HER-2 increased with the progression of gastric cancer stage. Among individual tests, CA724 has the best diagnostic efficacy, while the diagnostic efficacy of the combined detection of the three is significantly better than that of individual tests. Conclusion HP infection, abnormal serum tumor markers and positive expression of HER-2 are all closely related to the occurrence and development of gastric cancer. The combined detection of the three can significantly improve the diagnostic efficiency of gastric cancer, especially having important clinical value in the prediction of early gastric cancer and lymph node metastasis.

Gastric cancer; Helicobacter pylori; Tumor markers; HER-2; Joint testing; Diagnostic value