International Journal of Clinical Research

Objective To observe the effect and safety of remifentanil and sufentanil in the wake-up of idiopathic scoliosis surgery, and to provide a reference basis for the optimization of clinical anesthesia scheme. Methods From November 2025 to February 2026, 84 patients who underwent posterior idiopathic scoliosis deformity correction and internal fixation surgery in our hospital were selected as the research objects. They were divided into the control group and the experimental group by randomized numerical table method, with 42 cases in each group. The control group was maintained with sufentanil combined with propofol during the operation, and the group was maintained with remifentanil combined with propofol during the operation. The five core observation indexes of the operation wake-up time, wake-up quality, fluctuation amplitude of hemodynamic during wake-up period, the incidence of adverse reactions and the postoperative analgesic effect were compared between the two groups. Results The operation wakeup time in the experimental group was significantly shorter than that in the control group, and the rate of excellent wake-up was higher than that in the control group (P < .05). The average arterial pressure (MAP) and heart rate (HR) fluctuations in the experimental group were less than those in the control group during wake-up P < 0.05). The total incidence of adverse reactions in the experimental group was lower than that in the control group during the operation and within 24 hours the operation (P < 0.05). The visual analog score (VAS) scores at 2, 6, 12, and 24 after the operation in the experimental group were lower than those in the control group (P < 0.05). Conclusion Compared with Sufentanil can shorten the wake-up time, improve the quality of wake-up, maintain the stability of hemodynamics during wake-up, reduce the incidence of reactions, and provide better postoperative analgesic effect and higher safety for the anesthetic management needs of wake-up during surgery.

Remifentanil; Sufentanil; Idiopathic scoliosis; Intraoperative awakening; Anesthetic safety; Operative analgesia