International Journal of Clinical Research

Objective To systematically evaluate the clinical effect of probiotics-assisted subgingival scaling and root planing (SRP) in the treatment of chronic periodontitis. Methods Databases such as CNKI and PubMed were searched from 2020 to 2025 to collect randomized controlled trials (RCTs) on the treatment of chronic periodontitis with probiotics-assisted SRP. After literature screening and quality evaluation, a Meta-analysis was conducted using R software. Results A total of 12 RCTs (896 patients) were included, with 452 patients in the experimental group (SRP + probiotics) and 444 patients in the control group (SRP alone). The Meta-analysis showed that the periodontal pocket depth (PPD), gingival index (GI), and bleeding index (BI) of the experimental group were significantly lower than those of the control group at 3 and 6 months after treatment, and the clinical attachment level (CAL) was significantly better than that of the control group (all P < 0.05). Sensitivity analysis indicated that the results were stable, and the funnel plot suggested a slight publication bias but did not affect the reliability. Conclusion Probiotics-assisted SRP has a better clinical effect in the treatment of chronic periodontitis than SRP alone, and can significantly improve periodontal indicators and reduce inflammation.

Chronic periodontitis; Probiotics; Subgingival scaling and root planing; Meta-analysis; Randomized controlled trial