International Journal of Clinical Research

Objective To early evaluate myocardial damage in chemotherapy patients using non-invasive multi-parameter technology of myocardial strain and strain rate by tissue Doppler echocardiography, explore the impact of chemotherapy on the myocardium of breast cancer patients, and screen independent related factors of chemotherapy drugs' cardiac effects through multivariate analysis of patients' general clinical data, conventional echocardiographic parameters and cardiac tissue Doppler parameters. Methods A total of 64 female breast cancer patients receiving chemotherapy in Baoji Central Hospital from January 2024 to January 2025 were selected, and divided into the 3rd cycle of chemotherapy (T1) and the 6th cycle of chemotherapy (T2). The patients before chemotherapy (T0) were taken as the self-control group; general clinical data, conventional two-dimensional echocardiographic parameters, left ventricular myocardial systolic strain (ε), maximum systolic strain rate (SRs), early diastolic strain rate (SRe) and late diastolic strain rate (SRa) in each period were recorded, and the differences of each parameter between T0, T1 and T2 were measured and compared. Results Compared with the control group, there were no significant differences in LVDd, LVEF and mitral valve E/A ratio in the chemotherapy group (P>0.05); ε, SRs and SRe were significantly abnormal (all P<0.05), and there was no significant change in SRa (P>0.05). Conclusion Conventional echocardiographic parameters combined with multi-parameters of tissue Doppler, including ε, SRs, SRe and other parameters, can reflect the myocardial toxicity of chemotherapy drugs with specificity, which is earlier and more reliable, provide quantitative reference for clinical early detection of myocardial damage caused by chemotherapy drugs, and help clinical early myocardial protection measures for patients receiving chemotherapy.

Breast cancer; Chemotherapy; Myocardial tissue Doppler; Strain